With chaos all around them, the team must come to terms with how to rebuild after the Cabal’s attacks. Magnus takes a methodical approach to prove Ashley is still alive, while Will and Henry take on the daunting task of processing the hundreds of Abnormals who now seek refuge at the Sanctuary.

A disoriented Magnus wakes up to find the Sanctuary in ruins and the entire city decimated, with no memory of how the devastation occurred. While surveying the destruction, she is attacked by an inhuman creature but saved by two armed men who stun her and take her to an abandoned warehouse. After being hosed down and left shivering and exhausted, Magnus fears the worst when a battle-scarred figure enters the room.

Dr. Helen Magnus fights to save the life of one of the Sanctuary’s research scientists who was viciously attacked by a seemingly docile Abnormal. Baffled by the creature’s uncharacteristic behavior, Henry tries to figure out what, or who, caused the domesticated Abnormal to react so violently.

Will goes up against the heads of the Sanctuary Network to defend Magnus who is charged with a shocking murder. But as the evidence stacks up against her, even Will has trouble finding a way to convincingly defend her innocence.

While transporting a usually docile abnormal, Magnus's helicopter crashes, leaving her and Will stranded in the shaft of an abandoned oil rig. They soon find they are not alone in the water.

While an old friend of Magnus', a pouched abnormal named Jimmy, is handing over a fire elemental to the Sanctuary team, they are attacked by a gang of criminal abnormals from Chicago. The situation presents a lot of mysteries to be solved and quickly.

When rich youngsters begin to disappear after an apparent death and then come back to life, the trail leads Will & Magnus to a drug clinic in Mexico run by Nicola Tesla. Knowing his all-times plans, big trouble to be expected.

The team rescues the occupants of a sinking ship off the coast of South Africa and teleport them to the Sanctuary. However, Magnus suspects Druitt of murdering one of the passengers during the rescue.

The team investigate a murder in Mumbai, and find a connection to the ancient cult of Kali, whose followers can foretell disaster. However, Will falls ill and disappears, and is somehow linked to the mystery.

Will begins to experience strange visions that are connected to the Cult of Kali. Magnus has difficulty with finding the solution to their problems.