Holmes and Watson try to work a stateside investigation from London when someone close to them is gravely wounded by an unknown perpetrator in the United States. However, Holmes’ stateside legal trouble – the result of a confession to a murder he didn’t commit – threatens to derail their efforts.

Holmes takes extreme measures to secure his return to New York when he leans on his father’s disreputable connections to aid his legal re-entry into the United States. Also, while Holmes looks for a way back to the United States, Watson helps the NYPD investigate a murder at a storage facility that caters to wealthy clients with items they want hidden from U.S. Customs.

After an explosion at a traffic stop, Holmes and Watson must determine whether the attack was a terrorist attack; Holmes and Watson suspect there is more for them to discover regarding the recent attack on someone within their inner circle.

Tech billionaire Odin Reichenbach hires Holmes and Watson to investigate a personal threat he suspects originated from within his own company; Holmes and Watson search for a motive behind three seemingly unconnected murders.

Tech billionaire Odin Reichenbach presents Sherlock and Joan with an extraordinary offer to help him with a program that can predict future crimes. Sherlock and Joan assist Bell when he tries to prevent a future crime of his own, as he races to locate a fellow NYPD officer planning a sniper shooting.

Holmes and Watson search for an ulterior motive when Cassie Lenue, a brilliant young criminal they helped put in prison, seeks their help in solving a murder.

Holmes and Watson work to determine if a long dormant serial killer has resurfaced in the wake of a sculptor’s murder in New York City. Also, Watson suspects Holmes is keeping something from her regarding tech billionaire Odin Reichenbach.

Holmes and Watson receive a shocking request to collaborate from their foe, Odin Reichenbach, when the tech billionaire asks them to test his new crime prevention system. Tasked with investigating someone the program predicts will soon commit a crime, the duo worries Odin will take drastic action before they conclude their inquiry.

Holmes and Watson join forces with Holmes’ father, Morland, to enlist his vast criminal network to help disassemble tech billionaire Odin Reichenbach’s crime prevention system.

Tech billionaire Odin Reichenbach inadvertently provides Holmes and Watson with a lead that could give them evidence that brings him to justice.

Amidst Holmes and Watson’s battle with tech billionaire Odin Reichenbach, the investigators receive word of their old enemy and Sherlock’s former love, Jamie Moriarty.