Caught between a Gatling Gun and a fort full of murderous killers, Caine must rescue a stolen chalice in order to make restitution for a dead Franciscan priest.

While wandering in Mexico, Caine comes across an old woman and a young boy. The woman is trapped under a cart and asks Caine to take care of the boy. He takes him to a small Mexican village which believes it is under the spell of a warlock.

Caine helps a farmer who is married to an Indian woman. The townpeople have no respect for the farmer until he kills an outlaw's son and then they treat him as a hero.

Caine helps a young Indian man who saw his father killed and wants to kill the men who did it and rescue his mother from them.

Caine help a young Chinese orphan boy gain his freedom from a brutal master. The master goes to the Tong for help against Caine.

Caine is accused of taking part in a bandit ambush, and is taken prisoner by the U.S. Calvary. He meets a soldier that is a conscientious objector that helps him clear his name.

Caine comes to a bankrupt mining town and meets a mentally handicapped boy, who is the target of a claim jumper.

Caine meets a group of Hutterite settlers, who must reconsider their pacifist background when attacked by bigoted cattlemen, and teaches them how to defend themselves without compromising their principles.

Caine rescues the hawkers of the cure-all Theodora's Elixir from a hostile crowd, earning the come-hither gratitude of Theodora and the resentment of her jealous male partner.

A gunslinger defends Caine and the widow who owns the ranch where Caine is working. Meanwhile, Caine is still pursued by a detachment of volunteers and an overzealous bounty hunter.

The son of a deceased Texas Ranger tries to honor his memory by going after criminals his father kept a journal on. He finds more trouble than he expected and Caine must defend him.

Caine confronts a gang of Chinese immigrants that have taken to violence.

Caine recalls lessons learned as a youth when he and a Southern belle are trapped in a deep pit, held there by kidnappers.

Caine must defend prostitutes that want to start a new life with land bequeathed to them, from cattlemen that want to seize it for themselves.

Caine is caught in the middle of a land-rights fight between farmers and railroad agents. He tries to convince the farmers to accept an offer of amnesty, and to keep the agents from using the offer as a fatal trap for the farmers.

Caine tries to visit an unjustly jailed Shaolin student, but keeps being turned away. He then commits a crime so he can be put in jail with him, hoping to clear up an old misunderstanding and help free the student.

Wu Chang has angered the Tong Sect, and is ordered to commit suicide or be executed by them. Caine tries to help him fake his death and escape from the Tongs.

Caine and Serenity Johnson, the blind preacher last seen in Dark Angel, look for a killer that is stalking Serenity's town of Nineveh.

Caine meets Logan McBurney, a Scotsman who has hijacked a gold-transporting stagecoach named Old Ironsides, to haul an enormous box that he claims is his dead Sioux wife's coffin. Along the way to the burial ground, which is on Sioux land, Caine remembers times in the monastery, unaware that several robbers are following closely, hoping to take Old Ironsides for themselves.

Caine and Logan arrive at the Sioux burial ground, to bury what Caine believes is Logan's wife in a huge crate, and are confronted by angry Sioux warriors who feel they are trespassing. They must also deal with two robbers as well as the US Calvary. Caine recalls his own love story, that like Logan's wife, ended tragically.