When Tallulah Bankhead moves in next door Lucy reacts in typical fashion and continuous chaos ensues.

Ricky brings the gang to Las Vegas where he is performing. Lucy wants to hunt Uranium in the desert and Ricky doesn't want her to. Anyway, they meet Fred Mac Murray on the train to Las Vegas and he loses a lot of money gambling, so he wants to get on Lucy's scheme too before his wife finds out. To help her Uranium hunting scheme, Lucy has it printed in a fake newspaper and everyone starts looking for Uranium. Everyone is so involved that even Lucy thinks it's true. Anyway, Lucy throws the "Uranium sample" away and they later find it not knowing that it's a sample, so they all, not trusting each other try and race to the claims office. Who will get their first? Lucy? The Mertzes? Fred Mac Murray? Now I am not going to spoil that.

Lucy bugs Ricky about getting a horse for Little Ricky and he says "no". Lucy then wins a racehorse from sending in breakfast cereal box tops. When the horse appears at the house, Ricky comes home early and Lucy, Ethel, and Fred try getting the horse up the stairs. When he finds out, he blows his top. Ricky still says no and Betty Grable comes up with a plan of getting him in a race so that Little Ricky can get the horse. Well when Lucy finds out that the horse will do anything for her only, Lucy dresses up as a jockey and rides the horse until they win the race. But will the breaking of so many rules stop them?

Lucy and Ricky are about to go on a "2nd Honeymoon", but it falls through when Ricky has to do a TV show. Lucy and Ethel go by themselves and Lucy is upset. Lucy and Ethel meet Fernando Lamas at a ski lodge and they make friends. Lucy learns that Ricky and Fred are going after all and Lucy tries to teach Ricky a lesson for bailing out on her. She makes it look like there is something romantic between her and Fernando which causes pain and some black eyes.