
Tucker's running for student body president, but no one's paying his campaign any notice, and that includes his campaign managers: Danny and Sam. On a field trip to a museum to look at ancient Egyptian artifacts, everyone is surprised that the pharaoh in question looks just like Tucker. And when Tucker looks in a ghostly mirror, his image brings the pharaoh's minion, Hotep Ra, to life! Hotep Ra bows before Tucker and becomes his servant, urging him to not stand by anymore and be ignored. Tucker's new attitude -- with help from his new king's scepter -- gets him even more respect than he expected when he accidentally transports his friends and classmates to ancient Egypt during a school debate. Now, Tucker is a king, and it's hard not to enjoy the perks. Unfortunately, the servant Hotep Ra has his eye on Tucker's throne and some sinister plans in mind for the students of Casper High.
Danny and Sam get into a fight, and when Sam utters the words, "I sometimes wish I'd never met you," she finds herself in a world in which she and Danny are strangers. Worse than that, since it was Sam who encouraged Danny to check out the Fenton Portal the night he got his ghost powers, Danny doesn't have any powers! Now, Sam must convince Danny that they share a friendship and a history, and lead him back to the Fenton Portal for a second "accident" so he can again become Danny Phantom.
After being bitten by tiny green ghost beetles, the kids of Casper High get a mysterious illness that gives them ghost powers and are quarantined at a spooky old hospital outside of town. When Danny sneaks into the hospital to investigate, he is captured by Penelope Spectra and her assistant, Bertrand. They are the ones who started this illness as part of their plan to build Penelope a young and beautiful new body. All she needs is Danny's half-human/half-ghost DNA to complete her ghostly plan. With Danny captured and Sam sick, it's up to Tucker to conquer his fear of hospitals and free Danny before Penelope gets what she's after.