
Technus is back! But this is a new and improved Technus, a smoother operator who refuses to shout out his plans. Danny's not worried, especially after he splits himself in two and decides to leave the ghost hunting to his super hero side and allow his teen self some time off to just be "normal." Unfortunately, Danny Phantom, super hero, begins to take his job too seriously and Danny Fenton, average teenager, starts to enjoy slacking off way too much. Meanwhile, Technus electronically infiltrates the Fenton RV -- and, then, all of FentonWorks -- siphoning off the energy to complete his upgrade. It's up to the two Dannys to work together and defeat Technus 2.0 before he drains all the power from Amity Park, and then the world!
Danny and Sam get into a fight, and when Sam utters the words, "I sometimes wish I'd never met you," she finds herself in a world in which she and Danny are strangers. Worse than that, since it was Sam who encouraged Danny to check out the Fenton Portal the night he got his ghost powers, Danny doesn't have any powers! Now, Sam must convince Danny that they share a friendship and a history, and lead him back to the Fenton Portal for a second "accident" so he can again become Danny Phantom.
After being bitten by tiny green ghost beetles, the kids of Casper High get a mysterious illness that gives them ghost powers and are quarantined at a spooky old hospital outside of town. When Danny sneaks into the hospital to investigate, he is captured by Penelope Spectra and her assistant, Bertrand. They are the ones who started this illness as part of their plan to build Penelope a young and beautiful new body. All she needs is Danny's half-human/half-ghost DNA to complete her ghostly plan. With Danny captured and Sam sick, it's up to Tucker to conquer his fear of hospitals and free Danny before Penelope gets what she's after.