The team searches for Jessica, a 911 operator who disappeared after a man called and asked for her by name.

The team investigates when Malia Norton, a teenager at a detention center, disappears after being threatened by one of the other residents. Malia had been involved in a drinking and driving accident that had seriously injured her sister's boyfriend and killed another young man. The investigation at the detention center uncovers a lot of secrets that some of the residents would prefer to keep well hidden.

Jack and the team investigate when Sadik Marku's son goes missing along with the boy's mother, and Samantha worries that Jack is more interested in settling an old score with Marku than with finding the missing woman and boy.

The team investigates when Aaron Gibbs ends up missing one night and soon learn that he had been lying to his wife about quitting his job, and had been working nights in a fight club. During the course of the investigation, Jack and the others learn that Aaron's disappearance was connected to events that took place during Hurricane Katrina, when Aaron was fighting to save his sons, and follow the trail of evidence, believing that the events of that night in New Orleans hold the key to finding the truth about the missing man.

Martin brings the team in on the hunt for a young woman that went missing after a priest attempted to exorcise a demon from her. He begins to feel guilty when he finds out he used to work with her, but doesn't remember her.

Jack and the team investigate the disappearance of Alex Stark after his girlfriend reports him missing, and soon learn that Alex didn't own a cleaning business like he said he did but was actually involved in an illegal gambling operation. Jack goes undercover at a club that Alex would gamble at to find out what happened to him, and ends up being taken hostage by an associate of Alex's who becomes convinced that Jack is actually there to kill her. Unfortunately for Jack, his team believes that he has changed his cover story and has no idea that he's actually been kidnapped.

The team investigates the disappearance of social worker Eric Hayes, who had given thirty days notice to his job not long before. When their investigation leads them to a young pregnant woman who had already lost one child to the system, the agents begin to believe the disillusioned social worker may have been having an affair but soon discover that he may have been trying to right the wrong that drove him from his job. Danny has trouble with the investigation, as it reminds him of his own experience in foster care. Jack confides in Samantha about his relationship with Ann, but it may be too late.

Vivian thinks about her recent surgical problems while searching for a missing woman with a terminal condition.

When 17-year-old Ted Soros goes missing after a basketball game, the team begins an investigation, soon learning that Ted was an emancipated minor who was living on his own to attend a school with an exemplary basketball program. Learning he had recently contacted his mother with a request for legal advice from an uncle, the team begins to suspect that Ted may have done something that he could face criminal charges for, and realise that Ted's secret is connected to a university recruiting party. While the team works Ted's disappearance, Jack learns from Ann that she lost the baby, and waits for her at the clinic while she seeks medical attention.

The team tries to determine whether or not the recent disappearance of an air traffic controller has connections to the Middle East. The team soon learns that his wife died in an automobile accident and he was having an affair with her sister.

Barry Rosen goes missing shortly after being poisoned with bleach in a chili eating contest. While investigating Barry's disappearance, the team soon learns that he had been approached to throw the eating contest, and also that he had been spending a lot of time with a local prostitute in an effort to learn how to act around women. Danny is caught in the middle when Carlos asks him for a letter of reference in an upcoming custody review, and Elena informs him that Carlos is actually suing her for sole custody of Sofie. Danny warns Carlos that he is not going to be caught in the middle.

When a young artist disappears, the team is concerned that one of her subjects may have been unhappy with her work.

The team searches for missing water plant supervisor Jason Turner, and learn that he had become the target of a lot of anger after recent layoffs at the plant. Carlos comes to the office looking for Elena.

Elena is frantic when her daughter Sofie goes missing, and the team has a full schedule as they must also search for a missing female tourist named Jenny.

A newly elected senator goes missing and Jack immediately turns his attention towards her husband.

The team searches for a fifteen-year-old girl who lived with her grandfather and was last seen at an Internet café. Sam gets an unexpected visit from her estranged sister.

Sam's darkest secrets are revealed when her sister goes missing she decides to search for her without the team's help.

When a young, interracial boy goes missing, race and money appear to play the starring roles in the investigation.

A former soldier, now stuntman, goes missing and the team learns that he changed his will only short time before he went missing which makes them wonder who needed the money.

The team searches for Chris Manning, a family court judge with a soft side who went missing after meeting with a young boy caught between his mother and his abusive father. Suspicion initially turns anyone Manning may have riled up due to his court rulings, but after his clerk is shot in what appears to be an attempt on Manning's life, the team learns that the secret behind Manning's disappearance is tied up with something that happened over twenty years earlier.

A high school student goes missing after leaving her prom early to get some rest in her hotel room, leaving behind a bloody dress and a lot of questions about what may have happened to her.

A teenage girl disappears after joining a cult. In the office, Elena encounters problems with Carlos in their custody battle for Sofie.