Frank aids in the search for a man who is supposedly carrying a highly contagious virus and discovers the secret behind the Human Genome Project.

In rural Arkansas, Frank investigates the owner of a daycare center accused of child abuse, only to be accused himself.

In Manhattan, Frank Black and an anthropologist link a bizarre, ritualistic slaying to a lost tribe of Native Americans who follow apocalyptic prophecies.

On Halloween, Frank experiences eerie visions and strange events that spark flashbacks to his youth—and a telling encounter with a troubled World War II veteran.

Millennium Group offender profiler Frank Black investigates the abduction of a bus full of schoolchildren, requiring the help of fellow Group members Peter Watts and Lara Means as he tracks a man preparing for a third world war.

Frank and Watts travel to Germany where they seek a legendary Holy relic.

Novelist Jose Chung authors a short story critical of a millennial self-help movement... and performs some profiling of his own when a college professor is found murdered.

As Christmas approaches... Frank experiences visions from his childhood when Jordan claims to have been visited by the spirit of her dead grandmother.

Serial murders in the guise of assisted suicides stymie Frank, whose primary suspect is a charismatic hospice nurse. Frank and Lara investigate to determine if it is murder.

Frank searches for a young man who disappeared in the Alaskan wilderness. In the Alaskan wilderness, the body of a young adult male, its face crushed beyond recognition, drifts down a river.

A serial killer uses the internet as a medium for broadcasting his victims' murders.

Asylum inmates become prime suspects in a series of murders linked to an urban legend.

The discovery of the remains of the Crucifixion Cross threatens to divide the Millennium Group.

As the schism between the two warring Millennium Group factions deepens, Frank discovers the existence of yet another player in the power struggle.

A mysterious Asian woman is linked to several strange deaths aboard a ship.

Frank searches for a female serial killer and her lover after the pair escape from prison.

Catherine and Lara investigate when five girls claim they saw a vision of the Virgin Mary.

Frank senses that Bletcher's killer is responsible for the disappearance of a teenaged boy.

Four devils gather at a doughnut shop and swap stories about their dealings with mankind.

In this continuation of the previous episode... Jordan, Frank and Catherine bury the dead parakeet, prompting more questions from Jordan regarding God and the hereafter. Later, a Millennium team clad in bioharzard suits sweeps into the Davis home, where earlier an entire family was wiped out by the mysterious virus. Outside the house, in the backyard, are a dozen dead birds of various species.