When their laid-back boss Jack gets suddenly reassigned to Rome, the She Spies find themselves under the strict command of the mysterious Mr. Cross. Their first mission: protect arrogant pop star Rane Kennedy from a kidnapping threat.
When Cross' former colleague is murdered, it leads to a high-stakes confrontation with a dangerous arms dealer with a stolen bio-toxin. Soon, the She Spies infiltrate an exclusive auction where criminals bid for the weapon.