
When the adult film stars in Los Angeles start falling prey to a devastating disease, the hospital summons the assistance of the NIH team. At first, being as they are adult film stars, Connor suspects an STD. However, when the perfect housewife also falls prey to the same illness, a new link is needed to be found. After some testing, it is discovered that all of the women used the same plastic surgeon for breast implants. The team contacts the doctor, who is reluctant to help, but finally convince him to abide. The team tests the implants, but finds nothing. After some tough thinking, the team realizes that some fish and some water hold the answer.
When people in New York City start turning the color blue, the NIH team is called upon to help cure this outbreak. When searching for the cause, a diner holds an important clue.
A group of four teenage girls are suspected of having an STD when they are hospitalized for seizures. However, the NIH team must uncover the true cause of the seizures, and a pair of pants holds a clue.

When a couple of Iraqi War vets start showing signs of Gulf War Syndrome, the NIH team is called to investigate. However, when a group of Nursing-home residents fall ill with the same symptoms, the NIH team is left baffled. However, they are missing the bigger picture, where a lector holds an important clue.