John breaks the protocol of the Agent X Brotherhood to protect a former lover from members of a Washington D.C.- based cabal intent on taking down the President. Natalie, Malcolm and Judge Thorne work to unmask the members of the conspiracy.

The cabal trail leads John to a lawless Mexican town, where he is drawn into a deadly feud between the local drug lord and the town's police chief. Natalie probes into a romantic connection between her late husband and the fiancé of her political adversary.

A biological weapon is used in a failed assassination attempt, sending John, Natalie and Malcolm on a frantic race to thwart a domestic terrorist group's plans to deploy a virus on a greater scale.

John poses as a Secret Service agent and accompanies Natalie on a covert peace-talk mission. Before long, their helicopter is shot down and they're left stranded in the middle of nowhere, with very dangerous people on the hunt for them.

John wakes up in an Odessa basement, imprisoned by an unexpected captor; Malcolm works desperately to find and rescue John.

John travels in disguise to a party on a billionaire's island in hopes of stealing a dangerous, high-tech weapon; Natalie struggles to contain the fallout from the conspiracy against the President.

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